PUBLICATIONS

2024

Structural Basis for Mis18 Complex Assembly: Implications for Centromere Maintenance

Thamkachy R, Medina-Pritchard B, Park SH, Chiodi C, Zou J, Torre-Barranco M, Shimanaka K, Abad M, Páramo CG, Feederle R, Ruksenaite E, Heun P, Davies O, Rappsilber J, Schneidman-Duhovny D, Cho US, and Jeyaprakash AA

EMBO Rep, 2024

2023

Non-canonical MLL1 activity regulates centromeric phase separation and genome stability

Sha L, Yang Z, An S, Yang W, Kim S, Oh H, Xu J, Yin J, Wang H, Lenz HJ, An W, Cho US, Dou Y

Nat Cell Biol, 2023

Iditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy

Cobb T, Hwang I, Soukar M, Namkoong S, Cho US, Safdar M, Kim M, Wessells R, and Lee JH

PNAS, 2023

Batch production of high-quality graphene grids for cryo-EM: cryo-EM structure of methylococcus capsulatus soluble methane monooxygenase hydroxylase

Ahn E, Kim B, Park S, Erwin AL, Sung SH, Hovden R, Mosalaganti S, and Cho US

ACS Nano, 2023

2022

Development of an atmospheric plasma jet device for versatile treatment of electron microscope sample grids

Ahn E, Tang T, Kim BC, Lee HJ, and Cho US

Journal of Biological Chemistry, 2022

Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes

Ayoub A, Park SH, Lee YT, Cho US, and Dou Y

Biochemistry. 2021

2021

Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin

Lee YT, Ayoub A, Park SH, Sha L, Xu J, Mao F, Zheng W, Zhang Y, Cho US, Dou Y.

Nat Commun. 2021

2020

Dismantling and Rebuilding the Trisulfide Cofactor Demonstrates Its Essential Role in Human Sulfide Quinone Oxidoreductase

Landry AP, Moon S, Bonanata J, Cho US, Coitiño EL, Banerjee R.

J Am Chem Soc. 2020

Insights on the regulation of the MLL/SET1 family histone methyltransferases

Sha L, Ayoub A, Cho US, Dou Y.

Biochim Biophys Acta Gene Regul Mech. 2020

An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase

Raiymbek G, An S, Khurana N, Gopinath S, Larkin A, Biswas S, Trievel RC, Cho US, Ragunathan K.

Elife. 2020

2019

Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.

Park SH, Ayoub A, Lee YT, Xu J, Kim H, Zheng W, Zhang B, Sha L, An S, Zhang Y, Cianfrocco MA, Su M, Dou Y, Cho US.

Nat Commun. 2019

Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury

Cho CS, Kowalsky AH, Namkoong S, Park SR, Wu S, Kim B, James A, Gu B, Semple IA, Tohamy MA, Solanki S, Cho US, Greenson JK, Shah YM, Kim M, Lee JH.

Biochim Biophys Acta Gene Regul Mech. 2020

MMOD-induced structural changes of hydroxylase in soluble methane monooxygenase

Kim H, An S, Park YR, Jang H, Yoo H, Park SH, Lee SJ, Cho US.

Sci Adv. 2019

A Catalytic Trisulfide in Human Sulfide Quinone Oxidoreductase Catalyzes Coenzyme A Persulfide Synthesis and Inhibits Butyrate Oxidation

Landry AP, Moon S, Kim H, Yadav PK, Guha A, Cho US, Banerjee R.

Cell Chem Biol. 2019

Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket

Chik JK, Moiseeva V, Goel PK, Meinen BA, Koldewey P, An S, Mellone BG, Subramanian L, Cho US.

J Biol Chem. 2019

S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis

Yadav PK, Vitvitsky V, Kim H, White A, Cho US, Banerjee R.

J Biol Chem. 2019

2018

Mis16 Switches Function from a Histone H4 Chaperone to a CENP-A Cnp1-Specific Assembly Factor through Eic1 Interaction

An S, Koldewey P, Chik J, Subramanian L, Cho US.

Structure. 2018

Integrative Structural Investigation on the Architecture of Human Importin4_Histone H3/H4_Asf1a Complex and Its Histone H3 Tail Binding

Yoon J, Kim SJ, An S, Cho S, Leitner A, Jung T, Aebersold R, Hebert H, Cho US, Song JJ.

J Mol Biol. 2018

2017

Structure-based nuclear import mechanism of histones H3 and H4 mediated by Kap123

An S, Yoon J, Kim H, Song JJ, Cho US.

Elife. 2017

Structural and Mechanistic Insights into Hemoglobin-catalyzed Hydrogen Sulfide Oxidation and the Fate of Polysulfide Products

Vitvitsky V, Yadav PK, An S, Seravalli J, Cho US, Banerjee R.

J Biol Chem. 2017

2016

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

Lee JH, Cho US, Karin M.

Sci Signal. 2016

Biochemical Basis of Sestrin Physiological Activities.

Ho A, Cho CS, Namkoong S, Cho US, Lee JH.

Trends Biochem Sci. 2016

2015

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Kim H, An S, Ro SH, Teixeira F, Park GJ, Kim C, Cho CS, Kim JS, Jakob U, Lee JH, Cho US.

Nat Commun. 2015

Mis16 Independently Recognizes Histone H4 and the CENP-ACnp1-Specific Chaperone Scm3sp.

An S, Kim H, Cho US.

J Mol Biol. 2015

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes.

Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH.

Sci Rep. 2015

2013

Control of substrate access to the active site in methane monooxygenase

Lee SJ, McCormick MS, Lippard SJ, Cho US.

Nature. 2013