Epigenetics and Nuclesome
Histone Chapersones and nucleosome regulatory complexes further control the gene expression
mTORC pathway
Human Sestrin2 and GATOR1/2 complex as mTORC1 regulators
Cryo-EM Method Development
Development of cryo-EM grids to improve the sample preparation step
X-ray crystallography
(Advanced Photon Source)
Human MLL1-nucleosome complex
Human Sestrin 2
Nucleosome
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Structural Biology & Epigenetics

ABOUT US

Our laboratory is interested in illustrating the molecular mechanisms of key biological events using the structural biology as a primary tool. Using both X-ray crystallography and cryogenic electron microscopy (cryo-EM), we aim to determine the atomic resolution structures of target macromolecules. We are currently interested in structural studies of (1) key epigenetic regulators in complex with its substrate – nucleosome, (2) human Sestrin2 and mTORC1 regulators, and (3) the method development in cryo-EM sample preparation.

Office

4220E MSRB III

1150 W. Medical Center Dr., SPC 5606

Ann Arbor, MI 48109-0600

Phone

(734)764-6765

Email

uhnsoo@med.umich.edu

RESEARCH INTEREST

Epigenetic regulators in complex with the nucleosome

Human Sestrin2 and mTORC1 regulators

Grid development in cryo-EM

RECENT PUBLICATIONS

Development of an atmospheric plasma jet device for versatile treatment of electron microscope sample grids

Ahn E, Tang T, Kim BC, Lee HJ, and Cho US
J.Biol.Chem. 2022
Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes
LAyoub A, Park SH, Lee YT, Cho US, and Dou Y.
Biochemistry, 2021

Interested in our research?

We are always looking for talented and passionate People! Join our lab!